Nigerian Scientist, Akinsuyi Oluwamayowa links gut health to weak bones

It’s always inspiring to see Nigerians making significant strides globally, and Akinsuyi Oluwamayowa is one of our very own doing just that. Oluwamayowa has dived deep into an area that affects many but is discussed by few: osteoporosis, specifically he is exploring the connection between gut health and osteoporosis. This condition occurs when there is a dis balance between bone formation by osteoblast and bone breakdown by osteoclast. It  makes bones weak, and it’s especially problematic for our elderly population.

Oluwamayowa‘s research doesn’t just stop at identifying the problem; he’s gone a step further. In his latest paper, “Meta-Analysis Reveals Compositional and Functional Microbial Changes Associated with Osteoporosis”, he’s uncovered a unique connection. The study suggests that the bacteria in our gut, those tiny organisms we rarely think about, play a role in weakening our bones. Specifically his study revealed that there is dysbiosis in osteoporosis patients leading to the reduction of several beneficial microbes such as the SCFA producers.

Short-Chain Fatty Acids, or SCFAs, are little molecules that are super important for our health. Think of them like tiny helpers that are made when the good bacteria in our gut eat the fiber from our food. Now, these tiny helpers, the SCFAs, do a lot of good things for us. They keep our gut healthy, help our body use energy properly, and make sure our immune system, the body’s defense against germs, is working well. they even play important role in bone health. SCFAs are integral for the activation of G-protein-coupled receptors (GPCRs) present on the surface of bone cells, which play a crucial role in the regulation of bone metabolism. A reduction in SCFAs disrupts the normal functioning of these receptors, leading to imbalances in osteoblast (bone-forming cells) and osteoclast (bone-resorbing cells) activity. Specifically it leads to a decrease in osteoblast activity and a corresponding increase in osteoclast activity. This imbalance results in increased bone resorption over bone formation, leading to the decreased bone mineral density and weakened bone structure characteristic of osteoporosis.

Why is this important?

Well, most of the current drugs for osteoporosis only manage the symptoms. They don’t always get to the root of the problem, and they can come with side effects. Oluwamayowa’s study gives hope for new kinds of treatments that can address the root cause. For Nigeria, having a researcher like Oluwamayowa on the global stage is a point of pride. It showcases our talent, dedication, and the important contributions we’re making in the field of science and health. Let’s celebrate our own! A big shout-樂威壯 out to Akinsuyi Oluwamayowa for representing Nigeria so well and for his contributions to the world of medical research. We’re excited to see where his findings will take us in the quest for better health solutions. Stay tuned to this blog for more updates on incredible Nigerians making waves globally!